If you stick with a 16 foot line set, you can self-install just about any mini split since they all come precharged with R410A and require no extra charge. You will need common tools, a vacuum pump, optional nitrogen tank and optional micron vacuum gauge to do a self-install of any mini split. Some brands come precharged for up to a 25 foot lineset: check the specs of any you are considering to determine the precharged maximum and minimum lineset lengths (without having to add more refrigerant).
The Mr Cool DIY version saves you the purchase of a $140 vacuum pump kit off Amazon, but Mr Cool charges about $400 more for their DIY version than their standard version mini split. So the economics of the Mr Cool DIY version never made sense to me.
When you self-install, there are many hours of work regardless of brand: mount indoor and outdoor units, run 120V or 240 V wiring (both use same 12 awg wire typically for 12000 BTU or smaller), run the control cable, run the line set copper tubing, and figure out a downhill drain setup to drain the condensate in a/c mode.
I have done 9 self-installs. After everything is mounted, fastened and wired, I prefer to pressure test using a nitrogen tank and high pressure gauge, then vacuum down and check for leaks using a micron gauge. You can skip the pressure test and micron gauge with Mr Cool DIY but the pressure check and vacuum measurement get skipped by many self-installers, regardless of brand. I found a leak on one of my installs, so the pressure and vacuum tests have been worth it for me.
Yes the professional installs are 2x or more expensive: that is mostly labor for all that mechanical and electrical install. You can buy a good quality high HSPF (11.5 and up) mini split for the same price or less than Mr Cool DIY (check out Senville at sylvane.com), and end up with a low cost install, a system that saves you money every month, and a unit that works at very low outdoor temperatures.
If you care about a warranty, you will need to have the final pressure test and vacuum done by a certified HVAC technician: I had that step done professionally for $400 on my first mini split. All the rest of my 9 installs I have done everything myself and forego the warranty. All the mini split companies cancel warranty if you do the final line set testing step yourself. Since Mr Cool charges about $400 more for their DIY version than their standard version (roughly the cost of hiring a pro to do the line set test after you've done the rest of the install yourself), their DIY product essentially relies on FUD (Fear, Uncertainty and Doubt) of new users: a common marketing scheme.