After you get set up to where you think it's tuned and sighted in you should go out and shoot an arrow once in a while to check your sight while you are cold, not warmed up. This is where the bow will shoot for you in a hunting situation. Your muscles will be different cold than when used to shooting. Another thing is stump shooting. It's funny how a dot will shoot different than an imagined area. An equally weighted judo head makes for good practice and a lot of fun while scouting. Climb a hill and shoot while winded, shoot while kneeling, make sure your set-up isn't a critical tune. But to answer your question, yes, you can tweak too much on your bow to where you might 'go past' a good tune. These are reasons I go with heavy arrows, I get a good solidly tuned bow that shoots down the pipe in various situations.