What boat are you planning on bringing? Will it have room to sleep everyone on it?
I live in Juneau, spring of 2023 we bought a Duckworth 24 offshore without a trailer and ran it up to southeast Alaska. We made it from Anacortes to Ketchikan in 2 1/2 days. Last summer we spent 40 nights on the boat in Southeast Alaska and plan on about the same this year. It's pretty bare bones. We use a coleman stove on the filet table for cooking, a yeti to keep food cold, a 5 gallon bucket for a head, and harbor showers. I can't remember the minimum range you need in Canada, I want to say we were fueling every 160-180 miles. In southeast Alaska the longest stretch between fuel docks is Juneau to Petersburg at about 125 miles or Tenakee Springs to Petersburg, I want to say 180 miles though I can't remember off the top of my head. Fuel last summer was in the $4 gallon a range most places, the most expensive fuel we bought was in Thorne Bay. It's down in the $3.50 a gallon range currently.
AML is the main barge company servicing Southeast Alaska, last time I got a quote on shipping a trailer up it was $3k from Seattle to Juneau. The marine highway is the ferry from Bellingham, it's about $3k for 25' from Bellingham to Ketchikan. You can load a boat in Bellingham and pay someone to unload it in Alaska if you don't want to pay the expense of shipping your truck. Every ferry office should have some contact info for locals who will load/ unload trailers from the ferry. If you don't want to run the boat up the closest US port on the road system to the lower 48 is Skagway. I'd contact the harbor department though leaving a truck/ trailer there should be pretty reasonable. The Lynn Canal (Juneau to Haines/ Skagway) doesn't have great fishing or a ton to see, I'd plan on lauching from there and spending the majority of your time further south. There's the option to tow to Prince Rupert though I don't know anything about it, there's also Hyder Ak/ Stewart BC which may be closer than Skagway
If you can't sleep on the boat accommodations can be hard to come by and expensive. The best bang for your buck is forest service and state cabins at $45-$65 a night. The best ones are already booked for the summer though there's plenty of less popular options still open. Most will require a dinghy with 20' tides beaching isn't really practical unless your boat is light enough to drag a couple hundred feet up and down beaches. Tent camping is doable though not very common, some towns will have campground. Slips run $20-$30 a night without power for our boat. Most harbors have fresh water, bathrooms, and coin op showers. There are some free float docks throughout Southeast Alaska though they can be hard to find without local knowledge. We've started spending more and more nights on the hook there's a lot of great anchorages. Navionics is a great tool to find them though take the reviews from Yacht people with a grain of salt. We sleep on our boat and is a big reason we upgraded was the lack of lodging. Many times we'll plan on 1 direction and weather will force us another.
I wouldn't commit to 1 spot. Here's a couple notes on various spots
-Juneau fishing close to town isn't great, getting around without a car is hard, Stater harbor is a whale watching **** show though if you come in mid day you can find a spot to tie up. It does have the only costco in Southeast and a fair amount of marine supplies. Down town harbors are walking distance to down town Juneau and a grocery store
-Baranof warm springs, one of our favorite spots to spend a night or 2, well worth the stop if you can make it work fuel wise, the hot springs are amazing
-Petersburg is a fishing town and very boat freindly, great harbor, walking distance to the grocery store, hardware store, and resturants. The Wrangell narrows are an awesome stretch of water. People have great luck with halibut in the area
-Visit at least 1 glacier by boat, bobbing through ice burgs is a blast.
-Elfin cove is a sport fishing paradise. Free state dock, there's usually showers avilable at the general store. We go every June for Kings and September for Coho, decent halibut fishing in the area.
-Phybus bay area is where we've caught our biggest halibut
-Prince of whales is huge with some decent harbors and spots to stop
-Ketchikan isn't our favorite spot to spend time though they do have decent fishing, we just haven't spent much time fishing down there. The safeway is walking distance from Bar harbor for a resupply.
-Salmon fishing is usually going to be better the closer you are to the outside (open ocean)
Let me know what other questions you have.
Here's some random pictures from last summer