Having done wound ballistic seminars for police agencies for a few years, where agencies review/select their ammunition based on how it performs through ballistic gelatin and various barrier material ( jackets, shirts, wood, etc ) placed on or in front of ballistic gelatin.
Officers were encouraged to bring any ammunition they wanted to see perform and it was all shot, so they could see first hand, how the ammo performed.
No disrespect, but when officers saw how Glaser and Powerball performed, they started to unload their magazines and replace with other ammo. They had read all the hype, but had not seen how the ammo performs in real world situations they would be encountering.
You are looking for maximum expansion with no over penetration. Keeping in mind, if this is for home defense, what barrier materials may you be dealing with: Wall board (sheetrock ), door material and clothing.
Federal has some personal defense loads that feature lighter bullet weights, hollow point and reduced recoil for average shooter, making follow-up shots easier if necessary.
At the time, Speer Gold Dot, was the hands down performer in all ammo calibers.