Dan,
I've hunted Lewis and Clark NWR a few times and love the area. In my opinion, it's difficult to hunt until you put in the time to really learn it.
Most hunters seem to like the incoming tide, and hunting is reported to be best around Russian Island and Jim Crow Sands as well as toward the west end around Woody, Horseshoe, and Welsh Islands.
Most of my hunting has been around Marsh Island but I can't say I've ever had exceptional hunting there. Still trying to figure it out.
A boat blind or layout boat gives you some advantages; mostly allows you to set up without worrying so much about the effects of the tide on your blind and spread.
It's real easy to get stranded out there at low tide so be careful. Some guys take two boats, anchoring the big one in a safe place and using a small boat to explore and hunt.
Hope this helps a bit. Like I said, I'm still trying to figure it out myself.
Here are a couple urls you might find helpful:
http://terraserver.homeadvisor.msn.c...=1599&Z=10&W=2 http://terraserver.homeadvisor.msn.c...=1599&Z=10&W=2
regards....Mike