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Old 04-21-2008, 12:36 PM   #1
ncallero
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Default Serching for Sea Sickness Advice

I figure this is the best place to go for advice. I am addicted to rock fishing. I mainly fish depot/broiler bays and the Yaquina jettis. Last year I went on a few charters out of Newport fishing for the monster lings and had a blast until I got seasick. What is the best remedy or combination of remedies for seasickness? I am really looking for something that people swear by that works, no herbal extracts or teas or arm bracelets. Thanks
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Old 04-21-2008, 12:44 PM   #2
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Default Re: Serching for Sea Sickness Advice

There is some stuff that a friend uses that is really good ( I'll ask him the name) along with sucking on some ginger.
Just dont eat greasy foods or drink the night before and eat a very light breakfast with no grease.

If you get sick, make sure your buddies record it and post it on you tube. LOL.
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Old 04-21-2008, 01:08 PM   #3
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Default Re: Serching for Sea Sickness Advice

There is no one thing that works for everybody. All you can do is try them all.

Try taking Meclizine (generic for non-drowsy version of dramamine) before bed the night before and one in the morning.

For some people ginger tablets work.

A few things you can do to help is to keep an eye on the horizon. The horizon moves the way the brain is expecting based on what the inner ear feels. If you looking at a fixed object like the bottom of the boat you will probably get sick. Also, on the run out, sit in the back of the boat looking at land/horizon. There is less up and down motion in the back than up on the bow while underway.

Good luck.
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Old 04-21-2008, 01:08 PM   #4
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Default Re: Serching for Sea Sickness Advice

What worked for me was buying my boat and going a bunch. Crew members on my boat can tell you I used to get sick nearly every trip. I just dont anymore. Man it is great. I tried everything before my transmutation but none of it worked consistently. GoodLuck! I guess you could buy a boat, then all you would have to worry about is making the payments, fixing all the things that break, making sure no one tries to give you any help lest it be construed as some form of payment. Maybe it is worry that has cured my seasickness!
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Old 04-21-2008, 01:10 PM   #5
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Default Re: Serching for Sea Sickness Advice

Over the counter stuff like Dramimine works for most people
Take one prior to going to bed the night before and one an hour or 2 before boarding the boat

If that fails you need to get a prescription from your doctor
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Old 04-21-2008, 01:13 PM   #6
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Default Re: Serching for Sea Sickness Advice

Good advice on pre-loading dramamine, get good sleep, light breakfast,
and not to be crude, but making sure you have an empty system always helps me out.
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Old 04-21-2008, 01:24 PM   #7
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Default Re: Serching for Sea Sickness Advice

Been plagued with this my whole life

#1 for me is the patch behind the ear see your doc.
#2 plenty I mean plenty of rest the night before.
#3 be careful what you eat and drink the night before.
I've had great success with BONINE also.
Keep yourself busy. Ask the skipper if you can drive the boat look at the horizon not focus on something short range. Fresh air.
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Old 04-21-2008, 01:25 PM   #8
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Default Re: Serching for Sea Sickness Advice

I put on a Scopalamine patch the night before (prefereably at least 8 hours prior), try to get a good rest, and be well fed. I think the biggest key is to be physically rested. I find that the worst dyas for me are those following a long night getting ready or driving to the ramp.
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Old 04-21-2008, 01:31 PM   #9
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Default Re: Serching for Sea Sickness Advice

The only advice I have is do not buy whatever remedy you decide on prepackaged from store. Go back and ask for it from the pharmacist. They usually give you 50 pills for the same price it would cost for a dozen packaged ones.

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Old 04-21-2008, 01:41 PM   #10
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Default Re: Serching for Sea Sickness Advice

Drink Beer. Screws up your equilibrium.
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Old 04-21-2008, 01:42 PM   #11
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Default Re: Serching for Sea Sickness Advice

Scopalamine Patches. My lady got sick just crabbing in the bay. She got the patches and it was like a miracle. Fished Alaska last summer, and Halibut out of Newport with no problems. You have to go to the Doc for a Script.
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Old 04-21-2008, 01:44 PM   #12
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Default Re: Serching for Sea Sickness Advice

Dramine the night before, & first thing in the morning, don't drink/party the night before, go easy on the coffee, & eat a light breakfast to soak up the coffee, & dramanine does the trick for me, also 2 stroke, & diesel fumes can be enough to push me over the edge, so I reccomend 4 stroke motors for Ocean applications, but everybody is different so find a formula that works for you.
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Old 04-21-2008, 01:45 PM   #13
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Default Re: Serching for Sea Sickness Advice

Combination of Scopalamine (ear patch) and Bonine works for me when nothing else does. Start both the night before. Nothing else ever worked before. I got as sick as you have ever seen every time before this.
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Old 04-21-2008, 01:54 PM   #14
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Default Re: Serching for Sea Sickness Advice

The scopal "pill" works even better than the patch...still need a Dr. to get it...and it has a "pick-me-up" to keep you awake.

Not drinking too much the night before and eating a good breakfast has been key to a good day on the water...I've learned this the hard way in Cabo too many times.
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Old 04-21-2008, 02:15 PM   #15
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Default Re: Serching for Sea Sickness Advice

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Originally Posted by Haida1 View Post
Drink Beer. Screws up your equilibrium.

Drink a 1/2 can of beer when leaving the dock! Just be sure to leave it at 1/2! A little bit of beer actually settles your stomach.
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Old 04-21-2008, 02:18 PM   #16
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Default Re: Serching for Sea Sickness Advice

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Originally Posted by Fisherdaddy View Post
Combination of Scopalamine (ear patch) and Bonine works for me when nothing else does. Start both the night before. Nothing else ever worked before. I got as sick as you have ever seen every time before this.
This is the cocktail I use also. Without it I get very sick, with it I'm bulletproof.
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Old 04-21-2008, 02:21 PM   #17
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Default Re: Serching for Sea Sickness Advice

Start with meclazine. Its over the counter, cheaper and doesn't make me as drowsy (as bonine, or dramamine)
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Old 04-21-2008, 02:30 PM   #18
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Default Re: Serching for Sea Sickness Advice

Thanks Guys. Lots of great advice. So to be on the absolute safe side I plan on taking dramamine, bomine, and scopalamine the night before, going to bed at 5pm sober, waking up and eating a raw veggie breakfast, put on the patch and take more pills and chew on a mouth full of ginger. Oh and drink half a beer. Wish me luck.
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Old 04-21-2008, 02:41 PM   #19
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Default Re: Serching for Sea Sickness Advice

Shh, dont tell anyone, but... Scopolamine 0.5 mg and 5.0 mg Dexedrine. Some refer to it as NASA Candy. Ive never seen it fail yet (one exception was a very marginal day off the beach, when we couldn't decide if we would go or not and the guy was convinced he would get sick no matter what and took it as we were leaving the beach). It is schedule II, so you need a written Rx from your MD to get it.

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Old 04-21-2008, 02:54 PM   #20
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Default Re: Serching for Sea Sickness Advice

Lots of good advice here.

I prefer the scope pills these days, but seldom use them, always have them as well as genteric Mezerine (bi mart)

Chances are something herew ill work well for you.

1. Night before, ses sick meds, very little booze.

2. Good sleep w/ light breakfast

3. Soda or ritz crackers and small sips of water or ginger ale will help settle your stomach.

And if all else fails, just take 2 lunches. One for chum and one for you. I actually did this for many years. Finally last 4-6 years I seldom get sick at all anymore.
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Old 04-21-2008, 03:11 PM   #21
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Default Re: Serching for Sea Sickness Advice

What you need to do is get a hold of your doctor and get a prescription for SCOPACE. Rx only, but it works. I have never been sea sick before but I got a prescription to keep on the boat and those who have used it say it works great. Just take it an hour or so before you go. Not enough, take another if you feel sick. I'm not sure of the actual cost of the prescription, I work for a Hospital so I got good ins.
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Old 04-21-2008, 03:26 PM   #22
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Default Re: Serching for Sea Sickness Advice

Ginger root tablets from fred meyers and dramamine work great together, the sooner you start taking it the better
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Old 04-21-2008, 03:34 PM   #23
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Default your pharmacist recommends ......

scopace 0.4mg tablets. see your doc for a prescription. make sure you have no medical issues that preclude it's use. alan
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Old 04-21-2008, 03:42 PM   #24
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Default Re: Serching for Sea Sickness Advice

We also advised our crews to eat pancakes and wash them down with a milkshake
Any soft food works well but sweet foods taste better coming back up
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Old 04-21-2008, 03:52 PM   #25
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Default Re: Serching for Sea Sickness Advice

Dr. Tani should know, he's in the business. Scopace is the way to go, but like he said, be sure there are no issues, particularly heart, that would prevent you from using it. I've seen it used when the person was sick, took the pill and within 30 mins was good as new. Not for everyone and available by prescription only.

Eyes on the horizon, don't get your head down low when baiting, tying leaders, etc. and have a reasonable breakfast by staying away from the really good stuff like greasy bacon or sausage. More time on the water will, in all probability keep you feeling ok.
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Old 04-21-2008, 05:29 PM   #26
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Default Re: your pharmacist recommends ......

Quote:
Originally Posted by alantani View Post
scopace 0.4mg tablets. see your doc for a prescription. make sure you have no medical issues that preclude it's use. alan

Went to the doctor last year and got a bottle of this stuff haven’t been sick since. This is the way I went had tried to go out I have friends that have charter boats out of Depoe and went out with them and it was a laugh for them for me it was laying on a engine cover sick as a dog.
Went to the doctor seed I need something that I can use told him tried every thing try this and it works. Go out for a drink with the wife get up next morning and take the pill one hour before and no problem
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Old 04-21-2008, 05:37 PM   #27
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Default Re: Serching for Sea Sickness Advice

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Originally Posted by wdlfbio View Post
I put on a Scopalamine patch the night before (prefereably at least 8 hours prior), try to get a good rest, and be well fed. I think the biggest key is to be physically rested. I find that the worst dyas for me are those following a long night getting ready or driving to the ramp.
They make pills out of this wonder drug also. I had to explain the pill aspect to my doctor, but now get them over the phone with no office visit. They work great for me as a back up for lousy weather days and I can control the dosage better than the patch. Scopalamine is great.

Ya, what the Doc said, Scopace.

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Old 04-21-2008, 05:42 PM   #28
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Default Re: Serching for Sea Sickness Advice

i guess we could use my mother's old remedy. i came home with a hangover around christmas time when i was 16. she made me drink half a carton of eggnog and i spend the rest of the morning puking curdled eggnog. dad laughed so hard that he forgot all about being angry with me.

the other best thing to do when you're already sick is to eat bananas. i know they're bad luck on a boat, but they're the best thing to eat because they taste the same coming up as they do going down......
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Old 04-21-2008, 06:09 PM   #29
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Default Re: Serching for Sea Sickness Advice

The best combination is probably scopalamine and dexedrine. NASA did studies on this combination in the 70's to combat motion sickness with space flight. 5mg of dex and either a scop patch or a pill. Dramamine and dex also works and years ago was on the market as a combination drug Dramamine D.
50mg of Dramamine and 5mg of Dex. Make sure you have something in stomach as well
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Old 04-21-2008, 06:22 PM   #30
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Default Re: Serching for Sea Sickness Advice

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Shh, dont tell anyone, but... Scopolamine 0.5 mg and 5.0 mg Dexedrine. Some refer to it as NASA Candy. Ive never seen it fail yet (one exception was a very marginal day off the beach, when we couldn't decide if we would go or not and the guy was convinced he would get sick no matter what and took it as we were leaving the beach). It is schedule II, so you need a written Rx from your MD to get it.

Scott.
omg, i totally forgot about that one, doc! you can actually substitute 60mg of pseudoephedrine for the dexedrine and it should work pretty well.

careful with the patches. some guys cut them in half. if you get the gel in your fingers and then rub your eyes, your pupils will be dialated all day. we also had one poor guy that use a new patch every day. on the third day his pupils were dialated and he was hallucinating. he swore up and down that he did not eat the patches.
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Old 04-21-2008, 06:58 PM   #31
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Default Re: Serching for Sea Sickness Advice

All the best remedies have been mentioned - find what works best for you. My personal poison is old Dramamine, not the non-drowsy variety - the kind that makes you sleepy and gives you dry-mouth. One the night before, two a half hour before leaving the dock. Drink plenty of coffee and water, and you are good to go!
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Old 04-21-2008, 06:59 PM   #32
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Default Re: Serching for Sea Sickness Advice

its true bout the greasy food... ask my dad lmao!!!
He felt so sick last time we went out... And the funny thing is we had the same thing... but i had more... lol

but when we went out with Prowlers two years ago i took the D one the night before and was fine... just ate when i got out there and had my sea legs.
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Old 04-21-2008, 08:51 PM   #33
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Default Re: Serching for Sea Sickness Advice

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omg, i totally forgot about that one, doc! you can actually substitute 60mg of pseudoephedrine for the dexedrine and it should work pretty well.

careful with the patches. some guys cut them in half. if you get the gel in your fingers and then rub your eyes, your pupils will be dialated all day. we also had one poor guy that use a new patch every day. on the third day his pupils were dialated and he was hallucinating. he swore up and down that he did not eat the patches.
Isn't dexedrine an ADHD medication?
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Old 04-21-2008, 09:07 PM   #34
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Default Re: Serching for Sea Sickness Advice

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Originally Posted by smalldog View Post
There is some stuff that a friend uses that is really good ( I'll ask him the name) along with sucking on some ginger.
Just dont eat greasy foods or drink the night before and eat a very light breakfast with no grease.

If you get sick, make sure your buddies record it and post it on you tube. LOL.
ahaha No kidding. That's funny.

My sister is the most sea/car sickenist person I have ever met, but she gets what's called a Transderm Scop Patch and nothing gets her queezy. Scopolamine is the best way to go. Pill or patch.
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Old 04-21-2008, 09:09 PM   #35
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Default Re: Serching for Sea Sickness Advice

How could a stimulant keep you from getting sea-sick?
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Old 04-21-2008, 09:20 PM   #36
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Default Re: Serching for Sea Sickness Advice

O yea. Keep the heck outta the cuddy/cabin and heat. Going in and out, cold to hot to cold is a good way to disrupt things. Plus, like others said, keep your head up and eyes off the floor. Two years ago my buddy and I tried to cark a few fish onboard, fairly calm day. I got through one fish and felt the effects of bending over and not watching the horizon. At least I stopped before puking. Mike made 1/2 a fish and lost it. Puked about 6-8 times throughout the rest of the day. At least he and I were the only ones on board No more carking unless the boat is MUCH bigger (than 22').
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Old 04-21-2008, 09:24 PM   #37
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How could a stimulant keep you from getting sea-sick?
That's what I'm wondering!
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Old 04-21-2008, 09:49 PM   #38
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Default Re: Serching for Sea Sickness Advice

GraphiteZen, The stimulant won't help much with the motion sickness but will lessen the side effects of scopolomine.NASA can't have astronauts asleep at the wheel,probably helps when their whacked out driving cross country in diapers also.
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Old 04-21-2008, 10:50 PM   #39
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Default Re: Serching for Sea Sickness Advice

i think some flyboy had a few extra, decided to try it and found out that it worked. so many great discoveries were followed immediately by a "hmmm, now that's interesting .....".
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Old 04-22-2008, 12:11 AM   #40
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Default Re: Serching for Sea Sickness Advice

hehe ^^ I know that in Columbia scopolamine is used to drug people into all sorts of bad stuff. The substance comes from a root, and people are now extracting and dumping it into a persons drink, they come around two days later and their bank account is empty and they have no car... For real. Supposedly, if you get a person high on a heavy dosage of it and get them to focus on only you, they will do any and everything you tell them too... Some people even go so far as to mix it into coke and weed, get a person high and they are under your control... Pretty scary stuff, but if you stay under 0.5 mg you should be good to go and won't puke in heavy seas.
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Old 04-22-2008, 05:07 AM   #41
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Default Re: Serching for Sea Sickness Advice

I think the best solution is to get a bigger boat. If that size does not work, trade it in and go bigger.
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Old 04-22-2008, 08:12 AM   #42
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Default Re: Serching for Sea Sickness Advice

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Originally Posted by fyshndad View Post
We also advised our crews to eat pancakes and wash them down with a milkshake
Any soft food works well but sweet foods taste better coming back up
chocolate milk same goin down as coming up.
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Old 04-22-2008, 08:24 AM   #43
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best thing to do when you're already sick is to eat bananas. i know they're bad luck on a boat, but they're the best thing to eat because they taste the same coming up as they do going down......
As I have recently evolved into a "puker"...I find this statement HILLARIOUS!!!

I will call my doc....cause I really want to catch a TUNA!!
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Old 04-22-2008, 09:31 AM   #44
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one that works for me every time on my boat is keep their mined bussy. at the first sine of sicknes put them on kicked duty.
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Old 04-22-2008, 11:31 AM   #45
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Default Re: Serching for Sea Sickness Advice

When I fished commercially out of Alaska, I used to go to the bow and crash. Travel time is sleep time on a commercial salmon boat.
I would wake up with no sea sickness.
Standing around thinking about it would make me sick.
After a few weeks of being out...I was fine for the rest of the summer.
Like mentioned before. The more you go, the less you get sick.
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Old 04-22-2008, 01:05 PM   #46
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Default Re: Serching for Sea Sickness Advice

Ginger candy, gum, or cookies can help also.
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Old 04-22-2008, 02:46 PM   #47
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Default Re: Serching for Sea Sickness Advice

tape a penny to your belly button. don't know how many people this has helped when i used to spend all summer on the sporties in socal.
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Old 04-22-2008, 05:04 PM   #48
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Default Re: Serching for Sea Sickness Advice

Quote:
Originally Posted by okie man View Post
tape a penny to your belly button. don't know how many people this has helped when i used to spend all summer on the sporties in socal.


Placebos work everytime.
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Old 04-22-2008, 05:35 PM   #49
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Default Re: Serching for Sea Sickness Advice

I watched an episode of "Myth Busters" last year that tackled the sea sickness problem.
They tested Dramamine...some gadget you wear like a watch....patches...ginger pills...some other so called "seasickness cures" and the ONLY thing that worked with significant results was FRESH ginger. You can boil it up for tea or simply eat fresh slices of it.
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Old 04-23-2008, 06:57 PM   #50
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I think what ever method you end up using, if it is chemical, try it out on land first to make sure you won't have some unforseen reaction to it out in the yonder. Some medications like dramamine and scopolamine have antichlinergic side effects. They can decrease your ability to regulate heat by sweating, they can have effects on heart arrythmias, glalucoma, and for men with enlarged prostates it can sometimes cause acute urinary retention- can't pee. Happened to my dad. If you have any questions reaserch it yourself, read the package insert, or discuss it with your provider or pharmacist. Then take it onland first.
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Old 04-24-2008, 06:31 AM   #51
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Default Re: Serching for Sea Sickness Advice

Just a heads up on the dexidrine issue. I have used the NASA motion sickness formula for over ten years now. The last three the pharmacist has been unable to obtain any dexi to add to the mix. Uncle Sam has clamped down on the availability of the stuff. The scopalomine alone works just as well. I use it in a small sublinqual (under the tongue) tablet that I take about one hour before hitting the water. I also have a copy of the original NASA study that was done to see what motion sickness remedy worked the best on the astronauts. I got my copy from a friend who got in from Capt Kujo, who by the way, got it from NASA. The dexie was added to counteract the drowsiness effect of the scop, for those who were wondering what dexi has to do with flying a space ship. If you have the formula with dexi in it you are passing out a schedule II drug if you give any to empty seat riders. Scop alone is schedule IV I believe.

If anyone can still get the dexi, I would appreciate knowing the name and phone number of the pharmicist who can still get it. I will pass the info to my pharmicist so I can get back on the non drowsy formula. Thanks.

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Old 04-24-2008, 06:52 AM   #52
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Default Re: Serching for Sea Sickness Advice

Scopolamine is an extract from the jimsonweed plant. Scopolimine in doses larger than the individual patch, like multiple days of patches, will cause hallucinations, rapid heart rate, sweats, and of course dilated pupils.

Some herbal stores sell jimsonweed extracts. You can try those on for size without the script. Careful though Jimsonweed is the 3 most toxic plant indegenous to North America. Don't be thinking you can shortcut the pharmacist by eating some out of the back yard.

I wrote an article on jimsonweed that was later published. It was butchered when it was published but here is a portion:

http://www.lacity.org/LAPD/traffic/dre/eval0298.htm

I too use the patch. The first time, with my experience, I expected to spend the whole twelve hours waiting for it to kick in having hallucinations. Woke up about 30 times in the night worried I was hallucinating that I was sleeping. So much for the good night's rest the night before. I never am able to sleep the night before a fishing trip anyway. I'm like the kids on the Disney commercial "We're just too excited to sleep"

Last edited by dre5063; 04-24-2008 at 07:08 AM. Reason: wrong link- Sorry guys, that link is to St. Johns Wort not Jimsonweed. This is another article I had written.
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Old 04-24-2008, 07:46 AM   #53
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Default Re: Serching for Sea Sickness Advice

A local hospital did a study on motion sickness in conjuction with NASA a few years ago to find a remedy for the astronauts with motion sickness. What they found is a combination of Rx Phenergan 12.5 mg oral and 5.0 mg dexadrine. Usuall the phenergan like Dramimine and meclazine depresses the central nervous system and make you sleepy. Phenergan is a great anti nausea and is very inexpensive in it's generic form. The dexadrine is a synthetic amphetamine that counteract the depressant effect of the phenergan.
You would have to see you doctor for the prescriptions, but I`guarentee you that you would never feel sick.

my 2 cents
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Old 04-24-2008, 10:31 AM   #54
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Default Re: Serching for Sea Sickness Advice warning long post

phenergan is the number one antinausea used in the hospital. For this and all substances that have pharmacologic effect, discuss with your provider/pharmacist. read the package insert. review your health problems and other medications for interactions. Try it out on land first most importantly.
To give you an idea of what phenergan can do in the way of adverse effects, as well as costs; (by the way I use scopace take 1 tablet 1 hr prior, caffeine to replace dexamphetamine.)

ADVERSE REACTIONS SIGNIFICANT FOR PHENERGAN
Cardiovascular: Bradycardia, hypertension, nonspecific QT changes, postural hypotension, tachycardia
Central nervous system: Akathisia, catatonic states, confusion, delirium, disorientation, dizziness, drowsiness, dystonias, euphoria, excitation, extrapyramidal symptoms, fatigue, hallucinations, hysteria, insomnia, lassitude, nervousness, neuroleptic malignant syndrome, nightmares, pseudoparkinsonism, sedation, seizure, somnolence, tardive dyskinesia
Dermatologic: Angioneurotic edema, dermatitis, photosensitivity, skin pigmentation (slate gray), urticaria
Endocrine & metabolic: Amenorrhea, breast engorgement, gynecomastia, hyper-/hypoglycemia, lactation
Gastrointestinal: Constipation, nausea, vomiting, xerostomia
Genitourinary: Ejaculatory disorder, impotence, urinary retention
Hematologic: Agranulocytosis, aplastic anemia, eosinophilia, hemolytic anemia, leukopenia, thrombocytopenia, thrombocytopenic purpura
Hepatic: Jaundice
Local: Venous thrombosis; injection site reactions (burning, erythema, pain, edema)
Neuromuscular & skeletal: Incoordination, tremor
Ocular: Blurred vision, corneal and lenticular changes, diplopia, epithelial keratopathy, pigmentary retinopathy
Otic: Tinnitus
Respiratory: Apnea, asthma, nasal congestion, respiratory depression
CONTRAINDICATIONS — Hypersensitivity to promethazine or any component of the formulation (cross-reactivity between phenothiazines may occur); coma; treatment of lower respiratory tract symptoms, including asthma; children <2 years of age
WARNINGS / PRECAUTIONS
Boxed warnings:
  • Pediatrics: See "Special populations" below.
Concerns related to adverse effects:
  • Altered cardiac conduction: May alter cardiac conduction (life-threatening arrhythmias have occurred with therapeutic doses of phenothiazines).
  • Anticholinergic effects: Phenothiazines may cause anticholinergic effects (constipation, xerostomia, blurred vision, urinary retention); therefore, they should be used with caution in patients with decreased gastrointestinal motility, urinary retention, BPH, xerostomia, or visual problems.
  • Extrapyramidal symptoms: May cause extrapyramidal symptoms, including pseudoparkinsonism, acute dystonic reactions, akathisia, and tardive dyskinesia.
  • Neuroleptic malignant syndrome (NMS): Use may be associated with NMS; monitor for mental status changes, fever, muscle rigidity and/or autonomic instability.
  • Orthostatic hypotension: May cause orthostatic hypotension; use with caution in patients at risk of this effect or in those who would not tolerate transient hypotensive episodes (cerebrovascular disease, cardiovascular disease, hypovolemia, or concurrent medication use which may predispose to hypotension/bradycardia).
  • Sedation: May be sedating, use with caution in disorders where CNS depression is a feature; patients must be cautioned about performing tasks which require mental alertness (eg, operating machinery or driving).
  • Temperature regulation: Impaired core body temperature regulation may occur; caution with strenuous exercise, heat exposure, dehydration, and concomitant medication possessing anticholinergic effects.
Disease-related concerns:
  • Bone marrow suppression: Use with caution in patients with bone marrow suppression; leukopenia and agranulocytosis have been reported.
  • Cardiovascular disease: Use with caution in patients with severe cardiovascular disease.
  • Glaucoma: Use with caution in patients with narrow-angle glaucoma; condition may be exacerbated by cholinergic blockade. Screening is recommended.
  • Hepatic impairment: Use with caution in patients with severe hepatic impairment.
  • Myasthenia gravis: Use with caution in patients with myasthenia gravis; condition may be exacerbated by cholinergic blockade.
  • Parkinson's disease: Use with caution in patients with parkinson's disease; may have increased risk of tardive dyskinesia.
  • Renal impairment: Use with caution in patients with severe renal impairment.
  • Respiratory disease: Use with caution in patients with severe respiratory disease (asthma, COPD, sleep apnea); may lead to potentially fatal respiratory depression.
  • Seizures: Use with caution in patients at risk of seizures, including those with a history of seizures, head trauma, brain damage, alcoholism, or concurrent therapy with medications which may lower seizure threshold.
Concurrent drug therapy issues:
  • Antiemetic effects: May mask toxicity of other drugs or conditions (eg, intestinal obstruction, Reye's syndrome, brain tumor) due to antiemetic effects.
  • Sedatives: Effects may be potentiated when used with other sedative drugs or ethanol.
Special populations:
  • Pediatrics: [U.S. Boxed Warning]: Respiratory fatalities have been reported in children <2 years of age. In children ≥2 years, use the lowest possible dose; other drugs with respiratory depressant effects should be avoided.
Dosage form specific issues:
  • Sodium metabisulfite: Injection may contain sodium metabisulfite; may cause allergic reaction.
Other warnings/precautions:
  • Appropriate administration: Not for SubQ or intra-arterial administration. I.M. is the preferred route of parenteral administration. I.V. use has been associated with severe tissue damage; discontinue immediately if burning or pain occurs with administration.
DRUG INTERACTIONS — Substrate (major) of CYP2B6, 2D6; Inhibits CYP2D6 (weak)
(For additional information: Launch Lexi-Interact™ Drug Interactions Program )
Acetylcholinesterase inhibitors, central (donepezil, galantamine, rivastigmine, tacrine): May diminish the therapeutic effect of promethazine. Promethazine may diminish the therapeutic effect of centrally acting acetylcholinesterase inhibitors.
Anticholinergics: May inhibit the therapeutic response to phenothiazines and excess anticholinergic effects may occur; includes benztropine, trihexyphenidyl, biperiden, and drugs with significant anticholinergic activity (TCAs, antihistamines, disopyramide).
CYP2B6 inducers: May decrease the levels/effects of promethazine. Example inducers include carbamazepine, nevirapine, phenobarbital, phenytoin, and rifampin.
CYP2B6 inhibitors: May increase the levels/effects of promethazine. Example inhibitors include desipramine, paroxetine, and sertraline.
CYP2D6 inhibitors: May increase the levels/effects of promethazine. Example inhibitors include chlorpromazine, delavirdine, fluoxetine, miconazole, paroxetine, pergolide, quinidine, quinine, ritonavir, and ropinirole.
Pramlintide: May enhance the gastrointestinal anticholinergic effects of promethazine.
ETHANOL / NUTRITION / HERB INTERACTIONS
Ethanol: Avoid ethanol (may increase CNS depression).
Herb/Nutraceutical: Avoid valerian, St John's wort, kava kava, gotu kola (may increase CNS depression).
PREGNANCY RISK FACTOR — C (show table)
PREGNANCY IMPLICATIONS — Teratogenic effects were not observed in animal studies. Crosses the placenta. Possible respiratory depression if drug is administered near time of delivery; behavioral changes, EEG alterations, impaired platelet aggregation reported with use during labor.
LACTATION — Excretion in breast milk unknown/use caution
DIETARY CONSIDERATIONS — Increase dietary intake of riboflavin.
PRICING — (data from drugstore.com)
Solution (Promethazine HCl)
50 mg/mL (25): $69.99
Suppository (Phenergan)
12.5 mg (12): $47.99
25 mg (12): $54.99
50 mg (12): $69.99
Suppository (Promethazine HCl)
12.5 mg (12): $29.99
50 mg (12): $49.99
Suppository (Promethegan)
25 mg (12): $52.78
50 mg (12): $66.99
Syrup (Promethazine HCl)
6.25 mg/5 mL (118): $8.99
Tablets (Promethazine HCl)
50 mg (30): $21.99
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Old 04-24-2008, 01:09 PM   #55
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Default Re: Serching for Sea Sickness Advice

Ham and alapeno cheese sandwich, Beer and chips before crossing the bar.
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Old 04-24-2008, 01:47 PM   #56
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Default Re: Serching for Sea Sickness Advice

Most of the posts in this thread are helpful - i.e. the ones that say "this is what works for me". I think flapbreaker said it best when he mentioned there is no one thing that works for everybody. Don't count on the remedies from the guys who say "do this and I guarantee you won't get sick" Might work, might not.

If I don't take medication, I get sick 50% of the time, so it just isn't worth it to chance it. I use regular dramamine, but meclazine and bonine both work for me too. I hate the cotton mouth and sleepiness I get from the dramamine so will talk to my doctor about Scopace.

Last edited by Killertraylor; 04-24-2008 at 01:48 PM.
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Old 04-24-2008, 01:51 PM   #57
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Default Re: Serching for Sea Sickness Advice

Dang I feel like I just took a crash course

Way more info than I can digest but good to know what I did glean out of it

Sure am glad I have never gotten seasick and do not need this stuff
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Old 04-24-2008, 02:02 PM   #58
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Default Re: Serching for Sea Sickness Advice

Ifish...its not just for fishing any more.

Now the cop is coming out in me once again. No matter how much I try to keep my mouth quiet...it just doesn't work.

For those of you taking any of the prescriptions that are controlled substances...It is unlawful to operate any motor vehicle, including a boat, while being under the influence of ANY controlled substance. ORS 813.010 If you are adversely affected in any way by the prescription you could be charged with BUII. Most people think if you get it from the doc it's OK and that is not true. If it has a caution label on it that it may make you sleepy or effect your ability to operate machinery, the rule of thumb is you can be arrested if you ignore the warning.

Now...let the onslaught of email begin. Let me have it.
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Old 04-24-2008, 02:26 PM   #59
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Default Re: Serching for Sea Sickness Advice

Quote:
It is unlawful to operate any motor vehicle, including a boat, while being under the influence of ANY controlled substance.
Quote:
If you are adversely affected in any way by the prescription you could be charged with BUII.
You are determined to be "under the influence" if you have more than a .08 in your system, fail to pass field sobriety tests or drug recognition officer determines though his specialized training that you are intoxicated. You have to show impairment to be cited.

Last edited by GraphiteZen; 04-24-2008 at 02:29 PM.
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Old 04-24-2008, 02:29 PM   #60
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Default Re: Serching for Sea Sickness Advice

Zen, you are correct. There must be established impairment. I was not trying to infer there was no need to establish that. The comment I made was that IF YOU ARE ADVERSELY AFFECTED (that was meant to mean impaired). And most likely if you ingest a prescription in the manner in which it was prescribed, impairment would not be present. However, to err on the side of caution I made the preceding statement.
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